Vitamin B1 (Thiamine) vs. Vitamin B7 (Biotin / Vitamin H)
Comparing 2 standards across 10 specifications. 10 key differences identified.
Vitamin B1 is a water-soluble pyrimidine/thiazole vitamin acting as the Thiamine Pyrophosphate (TPP) coenzyme in pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. Adult RDA is 1.2 mg (men) / 1.1 mg (women) (no Upper Limit established).
Vitamin B7 is an essential sulfur-containing water-soluble vitamin serving as a prosthetic group for five carboxylase enzymes in gluconeogenesis, lipogenesis, and branched-chain amino acid catabolism. Adequate Intake (AI) is 30 µg/day (no Upper Limit established).
Specification Comparison Table
10 Parameters| Parameter / Spec | ||
|---|---|---|
|
Nutrient Type
|
Water-Soluble Thiazole Vitamin | Water-Soluble Ureido-Tetrahydrothiophene Vitamin |
|
Tolerable Upper Limit (UL)
|
None Established (Rapid renal clearance of excess) | None Established (No adverse effects recorded) |
|
Chemical Forms
|
Thiamine Monophosphate, Thiamine Pyrophosphate (TPP / TDP, active coenzyme), Benfotiamine (Lipid-soluble synthetic) | D-Biotin (Biologically active isomer), Biocytin (Biotinyl-lysine) |
|
Primary Biological Function
|
Pyruvate dehydrogenase complex (Links glycolysis to Krebs cycle), Transketolase (Pentose Phosphate Pathway), Myelin neurotransmission | Prosthetic group for Pyruvate Carboxylase (Gluconeogenesis), Acetyl-CoA Carboxylase (Fatty acid synthesis), Propionyl-CoA Carboxylase, Histone biotinylation |
|
Deficiency Condition
|
Beriberi (Wet beriberi: high-output heart failure; Dry beriberi: peripheral neuropathy), Wernicke-Korsakoff syndrome | Alopecia (Hair loss), Erythematous scaly periorofacial rash, Brittle nails, Neurological depression / hallucinations |
|
Top Whole Food Sources
|
Pork Tenderloin, Sunflower Seeds, Nutritional Yeast, Enriched Grains, Black Beans, Flaxseeds | Egg Yolk, Beef Liver, Salmon, Pork Chop, Sunflower Seeds, Almonds, Sweet Potatoes |
|
Adult RDA / RDI
|
1.2 mg / day (Men) / 1.1 mg / day (Women) (+0.3mg during pregnancy) | — |
|
Thermolability & Alcohol Interaction
|
Degraded by alkaline pH and high heat cooking; alcohol blocks intestinal active ThTr-1 transport | — |
|
Adult Adequate Intake (AI)
|
— | 30 µg / day (35 µg during lactation) |
|
Raw Egg White (Avidin) Interaction
|
— | Raw egg albumen contains avidin glycoprotein which binds biotin with Kd ~10^-15 M (the strongest non-covalent bond known), completely blocking absorption unless cooked |