E627: Disodium Guanylate (GMP Umami Synergist) vs. E631: Disodium Inosinate (IMP Meat Umami Synergist)
Comparing 2 standards across 9 specifications. 8 key differences identified.
E627 (Disodium 5'-Guanylate / GMP) is the sodium salt of guanylic acid, a purine nucleotide naturally concentrated in dried shiitake mushrooms. INS 627, ADI is Not Specified, exhibiting massive 8x–30x synergistic umami amplification when paired with MSG.
E631 (Disodium 5'-Inosinate / IMP) is the sodium salt of inosinic acid, a purine nucleotide naturally found in aged beef, katsuobushi bonito flakes, and cured meats. INS 631, ADI is Not Specified, multiplying glutamate umami flavor.
Specification Comparison Table
9 Parameters| Parameter / Spec | ||
|---|---|---|
|
E-Number Code
|
E627 | E631 |
|
INS / Codex Number
|
INS 627 | INS 631 |
|
Functional Class
|
Flavor Enhancer (Purine Nucleotide Umami Synergist) | Flavor Enhancer (Meat Purine Umami Synergist) |
|
Acceptable Daily Intake (ADI)
|
Not Specified (Quantum Satis) | Not Specified (Quantum Satis) |
|
Chemical Formula
|
C10H12N5Na2O8P · xH2O | C10H11N4Na2O8P · xH2O |
|
Primary Mechanism
|
Binds allosteric site on T1R1/T1R3 umami receptor, locking glutamate into the orthosteric binding pocket | Allosteric conformational stabilizer of human T1R1/T1R3 G-protein umami receptor heterodimer |
|
Common Target Foods
|
Savory snack seasonings (Doritos, chips), instant ramen noodle seasoning packets, bouillon cubes | Instant soups, meat seasonings, potato chips, canned meat gravies, cured snacks |
|
Dietary Compliance
|
Vegan (Microbial fermentation of tapioca/sugar), Halal, Kosher | Vegan (Bacterial Corynebacterium fermentation standard), Halal, Kosher |
|
Safety Approval
|
EFSA Authorized / FDA GRAS (21 CFR 172.530) | EFSA Authorized / FDA GRAS (21 CFR 172.535) |