Vitamin B2 (Riboflavin) vs. Vitamin D3 (Cholecalciferol)
Comparing 2 standards across 9 specifications. 9 key differences identified.
Vitamin B2 is an essential water-soluble isoalloxazine vitamin serving as the core structural component of Flavin Mononucleotide (FMN) and Flavin Adenine Dinucleotide (FAD) coenzymes in cellular redox respiration. Adult RDA is 1.3 mg (men) / 1.1 mg (women).
Vitamin D3 is a secosteroid prohormone synthesized endogenously in skin via solar UVB irradiation of 7-dehydrocholesterol. Adult RDA is 600–800 IU (15–20µg), with a Tolerable Upper Limit of 4,000 IU (100µg)/day, regulating systemic calcium absorption and immune gene expression.
Specification Comparison Table
9 Parameters| Parameter / Spec | ||
|---|---|---|
|
Nutrient Type
|
Water-Soluble Isoalloxazine Vitamin | Fat-Soluble Secosteroid Prohormone |
|
Adult RDA / RDI
|
1.3 mg / day (Men) / 1.1 mg / day (Women) | 600 – 800 IU / day (15 – 20 µg) |
|
Tolerable Upper Limit (UL)
|
None Established (Saturates intestinal absorption at ~27mg; excreted as harmless bright yellow urine) | 4,000 IU / day (100 µg) (Endocrine Society: up to 10,000 IU safe) |
|
Chemical Forms
|
Riboflavin, Riboflavin-5'-Phosphate (FMN), Flavin Adenine Dinucleotide (FAD) | Cholecalciferol (D3 - Animal/Lichen), Ergocalciferol (D2 - Fungi) |
|
Primary Biological Function
|
Complex I and Complex II mitochondrial electron transport chain cytochromes, Glutathione Reductase, B6/Folate activation | Calcitriol receptor (VDR) activation, intestinal calcium/phosphorus absorption, antimicrobial peptide synthesis |
|
Deficiency Condition
|
Ariboflavinosis (Angular cheilitis / cracked lip corners, glossitis / magenta tongue, seborrheic dermatitis) | Rickets (children), Osteomalacia (adults), Immune dysregulation |
|
Top Whole Food Sources
|
Beef Liver, Dairy Milk, Greek Yogurt, Eggs, Almonds, Portobello Mushrooms, Spinach | Sunlight UVB, Atlantic Salmon, Sardines, Egg Yolk, Fortified Milk |
|
Photodegradation Vulnerability
|
Extremely light-sensitive (dairy milk stored in clear glass loses 50% riboflavin within 2 hours of sunlight exposure) | — |
|
Target Serum 25(OH)D Level
|
— | 30 – 50 ng / mL (75 – 125 nmol / L) |