# item.guide

Magnesium (Elemental Mg)

Essential Vitamins & Minerals · 8 specs

Direct Answer

Magnesium is an essential macromineral required as an enzymatic cofactor in over 300 biochemical reactions including ATP synthesis, DNA replication, and neuromuscular transmission. Adult RDA is 400–420mg (men) / 310–320mg (women).

Source: NIH Office of Dietary Supplements / EFSA · Last reviewed Aug 28, 2026

Specs

Nutrient Type Essential Macromineral
Adult RDA / RDI 400 – 420 mg / day (Men) / 310 – 320 mg / day (Women)
Tolerable Upper Limit (UL) 350 mg / day (From supplemental forms only; no limit on whole foods)
Chemical Forms Magnesium Glycinate (Chelate), Citrate, Malate, Oxide, L-Threonate
Primary Biological Function Mg-ATP complex cofactor (>300 enzymes), NMDA receptor gatekeeper, Protein synthesis, Muscle relaxation
Deficiency Condition Muscle cramps, Tremors, Ventricular arrhythmias, Insulin resistance, Insomnia
Top Whole Food Sources Pumpkin Seeds, Hemp Hearts, Chia Seeds, Almonds, Spinach, Black Beans, Dark Chocolate
Cellular Distribution 99% intracellular (60% bone, 39% skeletal muscle, <1% serum)

The Mg-ATP Cellular Energy Complex

Adenosine triphosphate (ATP) is biologically active only when bound to an Mg2+ ion. Without adequate intracellular magnesium, cellular energy metabolism halts.

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