Iron (Heme & Non-Heme) vs. Vitamin B7 (Biotin / Vitamin H)
Comparing 2 standards across 10 specifications. 10 key differences identified.
Iron is an essential redox trace element central to hemoglobin oxygen transport, myoglobin storage, and mitochondrial electron transport chain cytochromes. Adult RDA is 8mg (men/post-menopausal women) / 18mg (pre-menopausal women), with a Tolerable Upper Limit of 45mg/day.
Vitamin B7 is an essential sulfur-containing water-soluble vitamin serving as a prosthetic group for five carboxylase enzymes in gluconeogenesis, lipogenesis, and branched-chain amino acid catabolism. Adequate Intake (AI) is 30 µg/day (no Upper Limit established).
Specification Comparison Table
10 Parameters| Parameter / Spec | ||
|---|---|---|
|
Nutrient Type
|
Essential Trace Mineral | Water-Soluble Ureido-Tetrahydrothiophene Vitamin |
|
Tolerable Upper Limit (UL)
|
45 mg / day (Hemochromatosis / Fenton reaction oxidative stress) | None Established (No adverse effects recorded) |
|
Chemical Forms
|
Heme Iron (Fe2+ Porphyrin - Animal), Non-Heme Iron (Fe3+ Ferric / Fe2+ Ferrous - Plants/Supplements) | D-Biotin (Biologically active isomer), Biocytin (Biotinyl-lysine) |
|
Primary Biological Function
|
Hemoglobin O2 transport, Myoglobin O2 storage, Cytochrome c electron transport, Catalase | Prosthetic group for Pyruvate Carboxylase (Gluconeogenesis), Acetyl-CoA Carboxylase (Fatty acid synthesis), Propionyl-CoA Carboxylase, Histone biotinylation |
|
Deficiency Condition
|
Microcytic Hypochromic Anemia, Severe fatigue, Restless legs syndrome, Pica | Alopecia (Hair loss), Erythematous scaly periorofacial rash, Brittle nails, Neurological depression / hallucinations |
|
Top Whole Food Sources
|
Beef Liver, Oysters, Duck Breast, Beef Ribeye, Lentils, Spinach, Dark Chocolate | Egg Yolk, Beef Liver, Salmon, Pork Chop, Sunflower Seeds, Almonds, Sweet Potatoes |
|
Adult RDA / RDI
|
8 mg (Men) / 18 mg (Women 19–50) / 27 mg (Pregnancy) | — |
|
Bioavailability Difference
|
Heme: 15–35% absorption (uninhibited); Non-Heme: 2–20% (inhibited by phytates/calcium, boosted by Vitamin C) | — |
|
Adult Adequate Intake (AI)
|
— | 30 µg / day (35 µg during lactation) |
|
Raw Egg White (Avidin) Interaction
|
— | Raw egg albumen contains avidin glycoprotein which binds biotin with Kd ~10^-15 M (the strongest non-covalent bond known), completely blocking absorption unless cooked |