# item.guide
Side-by-Side Comparison Essential Vitamins & Minerals

Vitamin B6 (Pyridoxal 5'-Phosphate / PLP) vs. Vitamin E (d-Alpha-Tocopherol)

Comparing 2 standards across 9 specifications. 9 key differences identified.

Comparing:
Vitamin B6 (Pyridoxal 5'-Phosphate / PLP)
Vitamin E (d-Alpha-Tocopherol)
Vitamin B6 (Pyridoxal 5'-Phosphate / PLP) →

Vitamin B6 is a water-soluble pyridine vitamin acting via its active coenzyme Pyridoxal 5'-Phosphate (PLP) in over 140 amino acid decarboxylation, transamination, and neurotransmitter synthesis reactions. Adult RDA is 1.3–1.7 mg, with a Tolerable Upper Limit of 100 mg/day.

View full Vitamin B6 (Pyridoxal 5'-Phosphate / PLP) spec sheet →
Vitamin E (d-Alpha-Tocopherol) →

Vitamin E is the principal fat-soluble peroxyl radical-scavenging antioxidant protecting cellular polyunsaturated membrane phospholipids. Adult RDA is 15 mg (22.4 IU) of d-alpha-tocopherol, with a Tolerable Upper Limit of 1,000 mg (1,500 IU)/day.

View full Vitamin E (d-Alpha-Tocopherol) spec sheet →

Specification Comparison Table

9 Parameters
Parameter / Spec
Vitamin B6 (Pyridoxal 5'-Phosphate / PLP)
Vitamin E (d-Alpha-Tocopherol)
Nutrient Type
Water-Soluble Pyridine Vitamin Fat-Soluble Chromanol Lipophilic Vitamin
Adult RDA / RDI
1.3 mg / day (Adults 19–50) / 1.7 mg (Men 51+) / 1.5 mg (Women 51+) 15 mg / day (22.4 IU) of 2R-alpha-tocopherol
Tolerable Upper Limit (UL)
100 mg / day (US FDA/NIH) / 12 mg / day (EFSA, revised down from 25mg in 2023) (Avoid sensory peripheral neuropathy) 1,000 mg / day (1,500 IU synthetic) (Excess impairs Vitamin K clotting cascade)
Chemical Forms
Pyridoxal 5'-Phosphate (PLP, active coenzyme), Pyridoxine HCl, Pyridoxamine RRR-alpha-Tocopherol (Natural d-alpha), all-rac-alpha-Tocopherol (Synthetic dl-alpha), Gamma/Delta-Tocopherols
Primary Biological Function
Transamination / deamination of amino acids, Serotonin / Dopamine / GABA synthesis from amino acids, Glycogen phosphorylase cofactor, Heme synthesis Breaks lipid peroxidation chain in PUFA cell membranes, protects LDL from oxidative modification, maintains erythrocyte membrane integrity
Deficiency Condition
Microcytic sideroblastic anemia, Seborrheic dermatitis, Cheilosis, Peripheral neuropathy, Convulsions Hemolytic anemia, Spinocerebellar ataxia, Peripheral neuropathy, Loss of vibratory/proprioceptive sense
Top Whole Food Sources
Chickpeas, Wild Salmon, Yellowfin Tuna, Beef Liver, Chicken Breast, Russet Potatoes, Bananas Wheat Germ Oil, Sunflower Seeds, Raw Almonds, Hazelnuts, Sunflower Oil, Spinach, Hass Avocado
Neurotoxicity Threshold
Chronic megadosing of Pyridoxine HCl (>200–500mg/day) causes reversible sensory neuropathy due to competitive inhibition of tissue PLP —
Hepatic Alpha-TTP Specificity
— The liver secretes only alpha-tocopherol into VLDL via Alpha-Tocopherol Transfer Protein (alpha-TTP); other tocopherols are degraded in bile

Other Alternatives to Compare

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